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Excessive stimulation of these receptors can lead to Ca influx, triggering pathological changes and neuronal damage, contributing to excitotoxicity

GHK-Cu is a naturally occurring copper-binding peptide studied for its role in cellular signaling pathways related to tissue support, extracellular matrix biology, and gene expression

Based on the published human data, topical formulations are the route with actual cosmetic-outcome evidence, albeit modest and from small studies

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J Am Soc Nephrol 28:23372352 Guenancia C, Li N, Hachet O, Rigal E, Cottin Y, Dutartre P, Rochette L, Vergely C (2015) Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice